Year 2

We have continued to collect blood samples from patients with Alzheimer’s disease, of varying age at onset, as well as well-characterized elderly controls. These will be used for reprogramming into pluripotent stem cells. Those can then be reprogrammed into other types of mature cells such as nerve cells or neurons. these can be used for research to understand mechanisms of aging, Alzheimer’s disease, and other disorders. The mechanisms of Alzheimer’s disease are incompletely understood. It is not possible to study nerve cells from patients with Alzheimer’s disease during life. Using stem cell technology enables such studies to occur.