The mission of the CIRM Shared Laboratory is to provide researchers with the resources to undertake pilot or long-term projects using stem cell technologies. These resources include basic training (each lab user must take a training course), advanced training and advice, and the use of high quality equipment. In addition to cell culture and cell biology facilities, our center has two unique features: high-throughput molecular profiling (Loring) and high throughput chemical screening (Ding). This shared stem cell lab continues its success and has established itself as a local stem cell hub. Each researcher, when qualified, supplies his or her own reagents and supplies, and works under the supervision of the dedicated staff. In the past year, many researchers from labs locally and nationally continue to use our shared stem cell lab for independent research projects, or participate in the training courses as summarized in details in the report.