This CIRM-funded project enabled development and validation of a novel injectable macroporous hydrogels as three-dimensional scaffolds for bone regeneration. Our results validate these scaffolds are injectable and can be delivered into defects in a minimally-invasive manner. It can be used alone to induce regeneration by stem cells from the body, or in combination with transplanted stem cells. The model also allow incorporation of additional drug delivery components to further enhance the speed of bone regeneration. Now that we have validated the safety of efficacy of this novel microribbon-based scaffolds for bone repair in a small animal model, they pave the road for future research to further validate the efficacy using large animal models.