The aims of the current proposal are to gain insight into the mechanisms of cardiac development as it relates to cardiac conduction system
and overall maturation of atria and ventricle. Our studies have identified a new key molecule that directs the maturation of cardiac cells. The secreted factor RSPO3 was found to have a significant role in the proper maturation of cardiac ventricles. We now aim to further identify the potential mechanisms by which RSPO3 Functions in the developmental maturation of the mammalian heart