Using our unique platform recapitulating the development of regular brain as well as the ones from Huntington’s disease patients in parallel and from pluripotent embryonic stem cells, we have been able to identify new class of compounds that constitute new therapeutic candidates for the treatment of Huntington’s Disease. In the future, we will probe the efficacy of these molecules at rescuing the Huntington’s disease pathology in animal models, towards reaching their application in the clinics.