Pluripotent Stem Cell–Based Therapy for Heart Disease
Five million people in the U.S. suffer with heart failure, resulting in ~60,000 deaths/year at a cost of $30 billion/year. Heart failure occurs when the heart is damaged and becomes…
A CIRM Disease Team for the Repair of Traumatically Injured and Arthritic Cartilage
Arthritis is a disabling condition that afflicts 6 million Californians, costing our state nearly $32 billion annually for health care and lost wages. Given the growth of an aging population…
Stem cell based treatment strategy for Age-related Macular Degeneration (AMD)
Retinal degeneration represents a group of blinding diseases that are increasingly impacting the health and well being of Californians. It is estimated that by 2020, over 450,000 Californians will suffer…
Motor neuron diseases: Finding cures through basic, translational, and clinical collaboration
Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) are motor neuron diseases. Motor neurons control the voluntary muscles that are used for activities such as crawling, walking, head and…
A CIRM Disease Team for the Treatment and Cure of Diabetes
This proposal is for the establishment of a group of faculty, staff and industrial partners to develop a proposal for a Diabetes Disease Team. Diabetes is one of the most…
Clinical Regenerative Wound Healing With Stem Cells
Chronic skin wounds affect a large number of patients every year who suffer from diabetes, burns, venous disease leg ulcers, arterial disease leg ulcers, pressure ulcers, and ulcers from spinal…
Stem Cell Gene Therapy for HIV in AIDS Lymphoma Patients
The Human Immunodeficiency Virus (HIV) is still a major health problem. In both developed and underdeveloped nations, millions of people are infected with this virus. HIV infects cells of the…
MSC engineered to produce BDNF for the treatment of Huntington’s disease
One in every ten thousand people in the USA has Huntington's disease, and it impacts many more. Multiple generations within a family can inherit the disease, resulting in escalating health…
Phase I study of IM Injection of VEGF Producing MSC for the Treatment of Critical Limb Ischemia
Critical limb ischemia (CLI) represents a significant unmet medical need without any approved medical therapies for patients who fail surgical or angioplasty procedures to restore blood flow to the lower…
Stem Cells Secreting GDNF for the Treatment of ALS
This project aims to use a powerful combined stem cell and gene therapy approach to treat patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig’s Disease). ALS is a devastating…
