CIRM Disease Team Planning Award
Children born with sickle cell anemia (SCA), caused by a genetic defect in hemoglobin, have severe anemia and damage to virtually all the body organs: the damage begins in infancy,…
{REDACTED} Heart Disease Regenerative Medicine Team Planning Award
The present planning grant application lays the groundwork for a collaborative heart disease regenerative medicine team. We plan to develop sequential preclinical and clinical investigations directed at regenerative stem cell-based…
Stem Cell-Mediated Oncocidal Therapy of Primary & Metastatic Brain Tumors
Brain tumors (BTs) are incurable, whether they start in the brain or spread there from other sites (e.g., lung, colon, breast, skin). Indeed, the latter situation is even more common…
Develop a cell replacement therapy for Parkinson’s disease using human embryonic stem cells
Parkinson’s disease (PD) is a devastating movement disorder caused by the death of dopaminergic neurons (a type of neurons in the central nervous system) present in the midbrain. These neurons…
Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa
The targeted disease is retinitis pigmentosa (RP), a severe form of blindness that runs in families. This disease is not common, yet represents an attractive near term target for stem…
Human Stem Cell Approaches to Alzheimers Disease Therapies
Alzheimer’s Disease (AD) is a major health problem in the U.S. with 10% of people over the age of 65 and 50% of people over the age of 85 afflicted…
Stem Cell Therapy for AIDS- Disease Team Planning
RNA interference is a naturally occurring means to block the function of genes in our body. We propose that RNA interference can be used to block HIV-1 infection and its…
Stem Cell Therapy for Muscular Dystrophy
The goal of our team is to capitalize on the remarkable advances in stem cell biology to apply those advances to the treatment of human diseases, disorders, and injuries. We…
Development of a Cell Replacement Therapy Product for Insulin Dependent Diabetes
With a current prevalence of greater than 170 million individuals world-wide, diabetes has attained epidemic proportions. The widespread secondary complications this disease extract a relentless and costly toll on the…
Development of a Stem Cell Therapy to Promote Functional Recovery in Stroke
Stroke is the leading cause of adult disability. As Californians adopt health measures that minimize stroke risk factors, such as high blood pressure and smoking, the number one risk factor…
