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Human pluripotent stem cell-based therapeutics for preeclampsia

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  • Post published:December 13, 2025
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Preeclampsia (PE) is a pregnancy complication, characterized by high blood pressure and abnormal kidney function, which affects 5-8% of all pregnancies. It is responsible for a significant proportion of maternal…

Continue ReadingHuman pluripotent stem cell-based therapeutics for preeclampsia

Preclinical evaluation of human embryonic stem cell-derived cardiovascular progenitors in a large animal model

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  • Post published:December 13, 2025
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Because the regenerative capacity of adult heart is limited, any substantial cell loss as a result of a heart attack is mostly irreversible and may lead to progressive heart failure.…

Continue ReadingPreclinical evaluation of human embryonic stem cell-derived cardiovascular progenitors in a large animal model

Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases.

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  • Post published:December 13, 2025
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Tissue specific stem and progenitor cells exist to replenish the tissue it resides during normal homeostasis or during regeneration from a wound. Disease and aging leads to a depletion of…

Continue ReadingRegulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases.

Epigenetic regulation of human cardiac differentiation

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  • Post published:December 13, 2025
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Each cell type in our body has its own identity. This identity allows a heart cell to contract repetitively, and a brain cell to conduct nerve impulses. Each cell type…

Continue ReadingEpigenetic regulation of human cardiac differentiation

Mechanism and Utility of Direct Neuronal Conversion with a MicroRNA-Chromatin Switch

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  • Post published:December 13, 2025
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Many human diseases and injuries that affect the brain and nervous system could potentially be treated by either introducing healthy neurons or persuading the cells that normally provide supporting functions…

Continue ReadingMechanism and Utility of Direct Neuronal Conversion with a MicroRNA-Chromatin Switch

Asymmetric stem cell division oriented by a local self-renewing signal

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  • Post published:December 13, 2025
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When stem cells divide, the two daughter cells have a choice. Commonly, one of the daughter cells becomes a new stem cell while the other one will be more specialized…

Continue ReadingAsymmetric stem cell division oriented by a local self-renewing signal

3D Modeling of Retina using Polymer Scaffolds for Understanding Disease Pathogenesis

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  • Post published:December 13, 2025
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Inherited retinal degenerations result in visual loss in patients as early as in their adolescence. Retinitis Pigmentosa includes a group of such degenerations which run in families and can result…

Continue Reading3D Modeling of Retina using Polymer Scaffolds for Understanding Disease Pathogenesis

Modeling disease in human embryonic stem cells using new genetic tools

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  • Post published:December 13, 2025
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The use of stem cells or stem cell-derived cells to treat disease is one important goal of stem cell research. A second, important use for stem cells is the creation…

Continue ReadingModeling disease in human embryonic stem cells using new genetic tools

Investigation of the role of O-GlcNAcylation in SOX2 function during reprogramming

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  • Post published:December 13, 2025
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Induced pluripotent stem cells (iPSCs) are a potential source of material for cell replacement therapies. Thus, achieving maximal efficiency of reprogramming will be important for cellular medicine. In this submission…

Continue ReadingInvestigation of the role of O-GlcNAcylation in SOX2 function during reprogramming

Induction of Pluripotent Stem Cell-Derived Pacemaking Cells

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  • Post published:December 13, 2025
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Currently, over 350,000 patients per year with abnormal heart rhythm receive electronic pacemakers to restore their normal heart beat. Electronic pacemakers do not respond to the need for changing heart…

Continue ReadingInduction of Pluripotent Stem Cell-Derived Pacemaking Cells
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