Progenitor Cells Secreting GDNF for the Treatment of ALS

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• Post published:January 7, 2026
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This project aims to use a powerful combined neural progenitor cell and growth factor approach to treat patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig’s Disease). ALS is a…

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Restoration of memory in Alzheimer’s disease: a new paradigm using neural stem cell therapy

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• Post published:January 7, 2026
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Alzheimer’s disease (AD), the leading cause of dementia, results in profound loss of memory and cognitive function, and ultimately death. In the US, someone develops AD every 69 seconds and…

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A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants

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Successful stem cell therapy requires the replacement of diseased or dysfunctional stem cells with healthy ones. These healthy stem cells can come from either a donor or can be stem…

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Phase I study of IM Injection of VEGF-Producing MSC for the Treatment of Critical Limb Ischemia

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• Post published:January 7, 2026
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Critical limb ischemia (CLI) represents a significant unmet medical need without any approved medical therapies for patients who fail surgical or angioplasty procedures to restore blood flow to the lower…

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MSC engineered to produce BDNF for the treatment of Huntington’s disease

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One in every ten thousand people in the USA has Huntington's disease, and it impacts many more. Multiple generations within a family can inherit the disease, resulting in escalating health…

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Neural stem cell transplantation for chronic cervical spinal cord injury

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1.3 million Americans suffer chronically from spinal cord injuries (SCI); each year ~15,000 individuals sustain a new injury. For California, this means nearly 147,000 individuals are living with a SCI…

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Treatment of non-traumatic osteonecrosis with endogenous Mesenchymal stem cells

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Although most individuals are aware that osteoporosis is disease of increased bone fragility that results from estrogen deficiency and aging, most are unaware of the high risk and cost of…

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Evaluation of Safety and Preliminary Efficacy of Escalating Doses of GRNOPC1 in Subacute Spinal Cord Injury

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The proposed project is designed to assess the safety and preliminary activity of escalating doses of human embryonic stem cell (hESC) derived oligodendrocyte progenitor cells for treatment of spinal cord…

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