Markus Muschen
Institution Name:
University of California, San Francisco
Total Awards:
1
Award Value:
$2,756,536
Awards as PI
| Program Type | Institution | Grant Title | Award Value |
|---|---|---|---|
| Early Translational II | University of California, San Francisco | Dual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication | $2,756,536 |
Total: $2,756,536.00 |
Publications
- Nature 2011 BCL6 enables Ph(+) acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. (PubMed: 21593872)
- J Exp Med 2011 BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. (PubMed: 21911423)
- Blood 2011 Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. (PubMed: 21856866)
- Blood 2012 Zebrafish screen identifies novel compound with selective toxicity against leukemia. (PubMed: 22490804)
- Immunity 2011 Control of B cell development by the histone H2A deubiquitinase MYSM1. (PubMed: 22169041)
- Nat Med 2013 BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. (PubMed: 23852341)
- Nat Genet 2014 RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. (PubMed: 24413735)
- Proc Natl Acad Sci U S A 2014 Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. (PubMed: 24821775)
- Nat Commun 2015 Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia. (PubMed: 25753524)
- Cancer Cell 2015 Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. (PubMed: 25759025)
- Nature 2015 Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. (PubMed: 25799995)
- Blood 2015 Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia. (PubMed: 25878119)
- Blood 2015 Ph+ ALL: drawing strength from a benign past. (PubMed: 25953975)
- Nat Immunol 2015 Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. (PubMed: 25985233)
- Cancer Cell 2015 Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. (PubMed: 26073130)