Deepak Srivastava
Institution Name:
Gladstone Institutes, J. David
Total Awards:
11
Award Value:
$19,368,651
Awards as PI
Awards as Co-PI
| Disease Team Therapy Development - Research | Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure |
Publications
- Cell 2010 Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. (PubMed: 20691899)
- Development 2010 The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. (PubMed: 21098571)
- Proc Natl Acad Sci U S A 2008 microRNA-138 modulates cardiac patterning during embryonic development. (PubMed: 19004786)
- Dev Cell 2009 Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. (PubMed: 19217425)
- Dev Cell 2008 miR-126 regulates angiogenic signaling and vascular integrity. (PubMed: 18694566)
- Sci Signal 2009 MicroRNAs: opening a new vein in angiogenesis research. (PubMed: 19126861)
- Circ Res 2009 MicroRNA regulation of cardiovascular development. (PubMed: 19325160)
- Cell Stem Cell 2008 MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. (PubMed: 18371447)
- Nat Cell Biol 2009 A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. (PubMed: 19620969)
- J Mol Cell Cardiol 2009 Notch1 represses osteogenic pathways in aortic valve cells. (PubMed: 19695258)
- Circ Res 2010 Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. (PubMed: 20558827)
- Cell Stem Cell 2010 MicroRNAs as regulators of differentiation and cell fate decisions. (PubMed: 20621048)
- Cell Cycle 2008 Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. (PubMed: 19066459)
- Nature 2009 miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. (PubMed: 19578358)
- Proc Natl Acad Sci U S A 2010 skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. (PubMed: 21071677)
- Dev Cell 2011 A Genome-Wide Screen Reveals a Role for microRNA-1 in Modulating Cardiac Cell Polarity. (PubMed: 21497762)
- Dev Biol 2011 Hand2 function in second heart field progenitors is essential for cardiogenesis. (PubMed: 21185281)
- Development 2011 A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. (PubMed: 21385766)
- Nat Cell Biol 2011 Notch post-translationally regulates beta-catenin protein in stem and progenitor cells. (PubMed: 21841793)
- PLoS One 2011 Elevated miR-499 levels blunt the cardiac stress response. (PubMed: 21573063)
- Circ Res 2012 miR-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting VEGF Signaling. (PubMed: 22955733)
- Stem Cells 2012 Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell Derived Endothelial Cells. (PubMed: 23079999)
- EMBO J 2013 Fending for a Braveheart. (PubMed: 23524853)
- Nat Protoc 2013 Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. (PubMed: 23722259)
- Stem Cell Reports 2013 Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. (PubMed: 24319660)
- Circ J 2015 Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine. (PubMed: 25744738)
- Science 2021 Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease. (PubMed: 33303684)
Videos
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