Clive Svendsen

Institution Name:

Cedars-Sinai Medical Center

Total Awards:

7

Award Value:

$24,867,857

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Awards as PI

Program Type	Institution	Grant Title	Award Value
Inception - Discovery Stage Research Projects	Cedars-Sinai Medical Center	Blood Brain Barrier (BBB)-on-Chip: Development and validation of a novel iPS-based microfluidic model of the human BBB	$241,992
Conference	Cedars-Sinai Medical Center	California ALS Summit 2012	$6,825
Clinical Trial Stage Projects	Cedars-Sinai Medical Center	Human Neural Progenitors Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral Sclerosis	$6,154,067
Tools and Technologies II	Cedars-Sinai Medical Center	Use of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy.	$1,933,022
Disease Team Therapy Planning I	Cedars-Sinai Medical Center	Stem Cells Secreting GDNF for the Treatment of ALS	$63,487
Disease Team Therapy Development - Research	Cedars-Sinai Medical Center	Progenitor Cells Secreting GDNF for the Treatment of ALS	$16,168,464
iPSC Consortia Award	Cedars-Sinai Medical Center	The HD iPSC Consortium: Repeat Length Dependent Phenotypes for Assay Development	$300,000
			Total: $24,867,857.00

Publications

PLoS One 2012 Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. (PubMed: 22723941)
Hum Mol Genet 2013 Back to the future: how human induced pluripotent stem cells will transform regenerative medicine. (PubMed: 23945396)
Sci Transl Med 2013 Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion. (PubMed: 24154603)
J Comp Neurol 2014 Human neural progenitor cells generated from induced pluripotent stem cells can survive, migrate, and integrate in the rodent spinal cord. (PubMed: 24610630)
Stem Cells Transl Med 2014 Reliable Generation of Induced Pluripotent Stem Cells From Human Lymphoblastoid Cell Lines. (PubMed: 25298370)
Neuroreport 2013 Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. (PubMed: 24284956)
Exp Neurol 2014 The past, present and future of stem cell clinical trials for ALS. (PubMed: 24613827)
J Vis Exp 2014 A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue. (PubMed: 24962813)

Videos

$18 Million ALS Research Grant for Stem Cell Therapy Applauded by ALS Advocates

$18 Million ALS Research Grant for Stem Cell Therapy Applauded by ALS Advocates

Progress Toward Stem Cell Therapies for ALS

Google Hangout: Progress Toward Stem Cell Therapies for ALS