Grant Award Details
Grant Application Details
- Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy
A vaccine booster to induce antigen-specific T memory stem cells that will help enhance the long-term immunity against cancer recurrence
Cancer recurrence presents an unmet medical need. Cancer vaccines are promising, but often lack a long-term protection. We will induce T memory stem cells (TMSCs) to boost the long-term immunity.
Major Proposed Activities
- To Develop Micro-/nanoparticles for a Sustained Release of Small Molecule and T Cell Activation Signals to Promote the Formation of TMSCs and Tumor-Antigen-Specific DCs In Vitro
- To Investigate the Induction of TMSCs by Injectable Cancer Vaccine Booster in Young and Aged Mice
- To Investigate the Prevention of Cancer Recurrence in Murine Models
Cancer recurrence presents an unmet medical need. Chemotherapy and radiation therapy have side effects. Cancer vaccines are promising, but may not achieve a long-term protection, especially in the elderly. Our approach can boost the therapeutic efficacy of the cancer vaccines, and help protect the patients with a more effective and less painful therapy, which will greatly reduce the burden of the healthcare and benefit the society.