Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy
Grant Award Details
Grant Type:
Grant Number:
DISC2-14169
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$2,267,714
Status:
Active
Grant Application Details
Application Title:
Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy
Public Abstract:
Research Objective
A vaccine booster to induce antigen-specific T memory stem cells that will help enhance the long-term immunity against cancer recurrence
Impact
Cancer recurrence presents an unmet medical need. Cancer vaccines are promising, but often lack a long-term protection. We will induce T memory stem cells (TMSCs) to boost the long-term immunity.
Major Proposed Activities
A vaccine booster to induce antigen-specific T memory stem cells that will help enhance the long-term immunity against cancer recurrence
Impact
Cancer recurrence presents an unmet medical need. Cancer vaccines are promising, but often lack a long-term protection. We will induce T memory stem cells (TMSCs) to boost the long-term immunity.
Major Proposed Activities
- To Develop Micro-/nanoparticles for a Sustained Release of Small Molecule and T Cell Activation Signals to Promote the Formation of TMSCs and Tumor-Antigen-Specific DCs In Vitro
- To Investigate the Induction of TMSCs by Injectable Cancer Vaccine Booster in Young and Aged Mice
- To Investigate the Prevention of Cancer Recurrence in Murine Models
Statement of Benefit to California:
Cancer recurrence presents an unmet medical need. Chemotherapy and radiation therapy have side effects. Cancer vaccines are promising, but may not achieve a long-term protection, especially in the elderly. Our approach can boost the therapeutic efficacy of the cancer vaccines, and help protect the patients with a more effective and less painful therapy, which will greatly reduce the burden of the healthcare and benefit the society.
Publications
- ACS Nano (2024): Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells. (PubMed: 38381620)
