Grant Award Details

Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy
Grant Number: 
DISC2-14169
Investigator: 
Name: 
Type: 
PI
Award Value: 
$2,267,714
Status: 
Pre-Active

Grant Application Details

Application Title: 
  • Vax-CT to promote formation of cancer-specific T memory stem cell for personalized cancer immunotherapy
Public Abstract: 

Research Objective

A vaccine booster to induce antigen-specific T memory stem cells that will help enhance the long-term immunity against cancer recurrence

Impact

Cancer recurrence presents an unmet medical need. Cancer vaccines are promising, but often lack a long-term protection. We will induce T memory stem cells (TMSCs) to boost the long-term immunity.

Major Proposed Activities

  • To Develop Micro-/nanoparticles for a Sustained Release of Small Molecule and T Cell Activation Signals to Promote the Formation of TMSCs and Tumor-Antigen-Specific DCs In Vitro
  • To Investigate the Induction of TMSCs by Injectable Cancer Vaccine Booster in Young and Aged Mice
  • To Investigate the Prevention of Cancer Recurrence in Murine Models
Statement of Benefit to California: 

Cancer recurrence presents an unmet medical need. Chemotherapy and radiation therapy have side effects. Cancer vaccines are promising, but may not achieve a long-term protection, especially in the elderly. Our approach can boost the therapeutic efficacy of the cancer vaccines, and help protect the patients with a more effective and less painful therapy, which will greatly reduce the burden of the healthcare and benefit the society.