Grant Award Details

Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes
Grant Number: 
DISC2-11175
Investigator: 
Disease Focus: 
Diabetes
Metabolic Disorders
Type 1 diabetes
Human Stem Cell Use: 
Embryonic Stem Cell
Cell Line Generation: 
Embryonic Stem Cell
Award Value: 
$1,637,209
Status: 
Pre-Active

Grant Application Details

Application Title: 
  • Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes
Public Abstract: 

Research Objective

Development of immune tolerant human islet-like organoids for transplantation into diabetic patients.

Impact

Our proposal will progress the development of an unlimited, reproducible source of immune tolerant engineered islets for transplantation into Type I diabetics.

Major Proposed Activities

  • Demonstrate efficacy of immune tolerant HILOs in humanized diabetic mice
  • Demonstrate safety of immune tolerant HILOs
  • Incorporate a “kill switch” into immune tolerant HILOs
Statement of Benefit to California: 

Diabetes affects 3 million people in California. Type 1 diabetes is a particular burden as it requires life-long administration of insulin. Allo- transplantation of islets is limited by availability of donor cells. This proposal will progress the development of functional islet-like organoids as an unlimited, reproducible source by engineering in immune tolerance to enhance and prolong functionality and survival upon transplantation into diabetic patients.