Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes

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Grant Award Details

Grant Number:
DISC2-11175
Investigator(s):
Human Stem Cell Use:
Cell Line Generation:
Award Value:
$1,637,209
Status:
Closed

Progress Reports

Reporting Period:
Year 2

Grant Application Details

Application Title:

Therapeutic immune tolerant human islet-like organoids (HILOs) for Type 1 Diabetes

Public Abstract:
Research Objective

Development of immune tolerant human islet-like organoids for transplantation into diabetic patients.

Impact

Our proposal will progress the development of an unlimited, reproducible source of immune tolerant engineered islets for transplantation into Type I diabetics.

Major Proposed Activities

  • Demonstrate efficacy of immune tolerant HILOs in humanized diabetic mice
  • Demonstrate safety of immune tolerant HILOs
  • Incorporate a “kill switch” into immune tolerant HILOs
Statement of Benefit to California:
Diabetes affects 3 million people in California. Type 1 diabetes is a particular burden as it requires life-long administration of insulin. Allo- transplantation of islets is limited by availability of donor cells. This proposal will progress the development of functional islet-like organoids as an unlimited, reproducible source by engineering in immune tolerance to enhance and prolong functionality and survival upon transplantation into diabetic patients.

Publications