Stimulating endogenous muscle stem cells to counter muscle wasting

Our goal is to improve human health by strengthening muscle in the elderly. Our previous work discovered that an injection of a PGE2 combination drug improved localized muscle atrophy. However, this strategy is therapeutically limited. Here, we show that a systemic treatment using a different approach to boost PGE2 levels shows similar effects without the drawbacks of a localized injection. Moreover, this approach is advantageous because it leads to a global increase in muscle strength throughout the body.  In the future, we will conduct additional research aimed at understanding how this drug affects cells to help muscles repair themselves.