Name:
Institution:
Type:
PI
Research Objective
Modified synthetic noncoding RNA molecule
Impact
Heart failure with preserved ejection fraction
Major Proposed Activities
The target indication is heart failure with preserved ejection fraction (HFpEF), a highly lethal disease refractory to medical intervention. HFpEF is increasing in prevalence, and now accounts for most hospital admissions for heart failure in California. HFpEF disproportionately afflicts disadvantaged populations (women, Blacks and Latinos, and the elderly). Because the therapeutic candidate is universally applicable, the societal benefits of success here are expected to be profound.