Grant Award Details

Modulation of the Wnt pathway to restore inner ear function
Grant Number: 
Project Objective: 
  • Identification of regimens of Wnt activators that stimulate hair cell regeneration.


Disease Focus: 
Hearing Loss
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 

Progress Reports

Reporting Period: 
Year 2 NCE Period

Grant Application Details

Application Title: 
  • Modulation of the Wnt pathway to restore inner ear function
Public Abstract: 

Research Objective

We aim to identify drug regimens that stimulate endogenous progenitors in the inner to regenerate to restore hearing or balance functions.


Treatment for irreversible hearing loss and balance disorders is limited, a drug regimen to reverse is highly impactful.

Major Proposed Activities

  • Production of R-spondin proteins
  • Drug testing in neonatal cochlear cultures
  • Drug testing in neonatal and mature utricle cultures
  • Drug testing in human utricle cultures
  • Drug testing in the cochlea in vivo
  • Drug testing in the utricle in vivo
Statement of Benefit to California: 

Hearing loss (HL) is a permanent sensory disorder affecting about 48 and 7.7 million people in the US and California. Another 90 and 14.5 million US and California residents suffer from dizziness and vertigo. Currently, treatment options including hearing aids aim at improving the symptoms of HL and dizziness, yet fail to reverse the main underlying pathology, loss of inner ear sensory hair cells (HC). The current research aims to characterize a drug regimen to reverse these sensory deficits.