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PI
Research Objective
The candidate is a fixed dose binary small molecule drug combination, consisting of two agents that act synergistically on a multipotent stem cell population in the CNS to stimulate remyelination.
Impact
The proposed studies will address bottleneck issues related to the effect size and tolerability of clinically validated remyelination drug classes.
Major Proposed Activities
It is estimated that >120,000 California residents suffer from multiple sclerosis (MS). This proposed research aims to provide a disease modifying therapy for MS. It will have a significant beneficial impact, by targeting the regenerative process known as remyelination, which becomes limiting during the progressive phases of MS disease.