Grant Award Details
To identify human prostate stem cell-associated surface markers that serve as potential targets for treating advanced prostate cancer.
Grant Application Details
- Identification of stem cell surface markers as potential therapeutic targets for advanced prostate cancer
The goal of this proposal is to identify proteins found on the surface of both human prostate stem cells and cancer cells that could be used as potential targets for treating advanced prostate cancer.
There is no cure for advanced prostate cancer. This combined with the success of treating other cancers by targeting features unique to stem cells highlight the potential impact of our proposal.
Major Proposed Activities
- Characterize human prostate stem cell subpopulations found in normal tissue by their molecular signatures and functional traits
- Identify unique markers found on the surface of prostate stem cells that are also overexpressed in advanced prostate cancers
- Develop antibodies against prostate stem cell associated surface markers and test their ability to target advanced prostate cancer
Prostate cancer accounts for approximately 3,500 deaths each year in California. The lack of effective treatments for advanced prostate cancer and the appearance of resistance mechanisms to current drugs underscore the need to develop new therapeutic strategies. Our approach of targeting normal stem cell traits that are also found in advanced prostate cancer could potentially revolutionize how we treat men living with this debilitating disease.