Global gene expression profiling of single inhibitory neurons derived from human stem cells

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Grant Award Details

Grant Type:
Progression Award – Discovery Stage Research Projects
Grant Number:
DISC2P-11700
Investigator(s):
Name:
Dr. Cory R Nicholas
Institution:
Neurona Therapeutics
Type:
PI

Disease Focus:
Epilepsy, Neurological Disorders
Human Stem Cell Use:
Embryonic Stem Cell
Award Value:
$202,500
Status:
Closed

Progress Reports

Reporting Period:
Year 1

Grant Application Details

Application Title:

Global gene expression profiling of single inhibitory neurons derived from human stem cells

Public Abstract:
Research Objective

This study will use high throughput single-cell capture and next-generation sequencing technologies to resolve the composition of an emerging neuronal cell therapy product.

Impact

If successful, this study will facilitate robust manufacturing processes and analytical methods toward a potentially safer and more effective cell therapy product.

Major Proposed Activities

["Characterize the cellular composition of three independent lots of product", "Determine the long-term cell fate of the product following transplantation into a preclinical animal model"]
Statement of Benefit to California:
If successful, this study will directly benefit the 400,000 people living with epilepsy in the State of California, of which approximately one-third are multi-drug resistant. Additionally, the single-cell capture, sequencing, and gene expression analysis tools could potentially be used to improve and accelerate the development of other regenerative stem cell-based therapies.

Publications