Gingival mesenchymal stem cells as a novel treatment modality for periodontal tissue regeneration
Grant Award Details
Grant Type:
Grant Number:
DISC1-10718
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$194,483
Status:
Closed
Progress Reports
Reporting Period:
Year 2
Grant Application Details
Application Title:
Gingival mesenchymal stem cells as a novel treatment modality for periodontal tissue regeneration
Public Abstract:
Research Objective
To develop a novel regenerative and adhesive hydrogel encapsulating patient's' gingival stem cell which can potentially be used as an adhesive dental hydrogel for periodontal tissue regeneration.
Impact
Upon successful completion, this project will introduce a promising treatment approach for maxillofacial defects presenting an innovative treatment modality for periodontal tissue regeneration.
Major Proposed Activities
To develop a novel regenerative and adhesive hydrogel encapsulating patient's' gingival stem cell which can potentially be used as an adhesive dental hydrogel for periodontal tissue regeneration.
Impact
Upon successful completion, this project will introduce a promising treatment approach for maxillofacial defects presenting an innovative treatment modality for periodontal tissue regeneration.
Major Proposed Activities
- Utilizing human GMSCs as a promising source for periodontal tissue regeneration.
- To optimize the physiomechanical properties of the visible-light curable adhesive hydrogel for GMSCs encapsulation.
- To engineer light curable hydrogel loaded with GMSC/HAp microparticles aggregates or TGF-β3 growth factor for periodontal tissue regeneration in vitro.
- To optimize and determine the functionality of GMSCs-hydrogel system via relevant animal model.
Statement of Benefit to California:
Periodontitis is a prevalent chronic destructive inflammatory disease affecting tooth-supporting tissues in humans. Approximately 50% of Americans have some form of periodontal diseases. In this proposal, we aim to engineer a novel regenerative and adhesive hydrogel containing patient's' gingival stem cell aggregates/hydroxyapatite microparticles and growth factor, which can potentially be used as an adhesive dental hydrogel for periodontal tissue regeneration.
Publications
- Sci Transl Med (2020): An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats. (PubMed: 32161103)
