Grant Award Details
- The overall objective of this project is to maximize the therapeutic viability of an immune-shielded, glucose-responsive human islet-like organoids (HILOs) as a cure for type 1 diabetes by demonstrating their efficacy and long-term survival.
Grant Application Details
- Extending Immune-Evasive Human Islet-Like Organoids (HILOs) Survival and Function as a Cure for T1D
Determine optimal islet transplant conditions and systemic treatments that promote graft survival upon transplantation into immune-competent diabetic subjects.
Our proposal will optimize the generation and viability of an unlimited, reproducible source of human engineered islets for transplantation.
Major Proposed Activities
- Demonstrate improved HILO graft survival with FGF1 coating
- Prolong grafted HILO survival by reducing metabolic insulin demand
Diabetes affects 3 million people in California. Type 1 diabetes is a particular burden as it requires life-long administration of insulin. Allo-transplantation of islets is limited by availability of donor cells. This proposal will facilitate the generation of functional ESC-derived islet-like organoids as an unlimited, reproducible source and optimize methods to increase functionality and viability upon transplantation into diabetic patients.