Grant Award Details
To develop an angiogenic proteoglycan mimic that will protect tissue from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing.
Progress Reports
View Report
Grant Application Details
- Development of treatments to improve healing of ischemic wounds
Research Objective
We aim to develop an angiogenic proteoglycan mimic that will protect tissue from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing.
Impact
As a treatment, LXW7-DS-SILY combined with a collagen scaffold and EPCs will accelerate healing of ischemic diabetic foot ulcers and reduce limb amputation and mortality rates of diabetic patients
Major Proposed Activities
- Aim 1. Synthesize and characterize the angiogenic potential of LXW7-DS-SILY
- Aim 2. Quantify the effect of LXW7-DS-SILY and EPCs delivered with a 3D collagen scaffold on ischemic wound repair in a diabetic ischemic wound model
We expect that LXW7-DS-SILY combined with a collagen scaffold and EPCs will lead to a novel treatment to accelerate healing of ischemic diabetic foot ulcers, thereby reducing limb amputation and mortality rates of diabetic patients. We further anticipate that the results from the proposed studies will support translational activities to bring this therapy to patients.
Publications
- ACS Biomater Sci Eng (2021) Proangiogenic Collagen-Binding Glycan Therapeutic Promotes Endothelial Cell Angiogenesis. (PubMed: 34192455)