Grant Award Details

Development of treatments to improve healing of ischemic wounds
Grant Number: 
DISC1-10516
Project Objective: 
  • To develop an angiogenic proteoglycan mimic that will protect tissue from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing.

Investigator: 
Type: 
PI
Disease Focus: 
Vascular Disease
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 
$235,800
Status: 
Active

Grant Application Details

Application Title: 
  • Development of treatments to improve healing of ischemic wounds
Public Abstract: 

Research Objective

We aim to develop an angiogenic proteoglycan mimic that will protect tissue from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing.

Impact

As a treatment, LXW7-DS-SILY combined with a collagen scaffold and EPCs will accelerate healing of ischemic diabetic foot ulcers and reduce limb amputation and mortality rates of diabetic patients

Major Proposed Activities

  • Aim 1. Synthesize and characterize the angiogenic potential of LXW7-DS-SILY
  • Aim 2. Quantify the effect of LXW7-DS-SILY and EPCs delivered with a 3D collagen scaffold on ischemic wound repair in a diabetic ischemic wound model
Statement of Benefit to California: 

We expect that LXW7-DS-SILY combined with a collagen scaffold and EPCs will lead to a novel treatment to accelerate healing of ischemic diabetic foot ulcers, thereby reducing limb amputation and mortality rates of diabetic patients. We further anticipate that the results from the proposed studies will support translational activities to bring this therapy to patients.