CIRM Training Program
This application proposes to continue, and expand, our CIRM-funded integrated training and research program in the fundamental biology of embryonic stem cells, nuclear reprogramming, tissue- and organ-specific stem cells and cancer stem cells. We aim to produce the next generation of leaders positioned to understand basic stem cell mechanisms, develop relevant human stem cell lines for investigation into pathogenesis and treatment of diseases, and provide the basis for development of new molecular and cellular therapies. During the previous funding period, the CIRM Training program has been highly-successful and vital to our stem cell efforts, providing valuable resources for both Scholars and the greater community in which they are educated. Our Program offers outstanding opportunities for training predoctoral, postdoctoral and clinical Scholars, in stem cell biology, regenerative medicine, and human disease. Because the School of Medicine, Hospitals, and the University are situated on one campus, our Program brings a powerful combination of assets to this mission. Our faculty have extensive experience in basic research, clinical translation, and training in stem cell biology and medicine. Moreover, our Program is strongly committed to stem cell biology. In 2002, we established a regenerative medicine institute, which nucleated a University-wide Program in Regenerative Medicine that promotes interactions between Departments and Programs in the Schools of Engineering, Law, Humanities & Sciences, Business, Medicine, and an interdisciplinary program in biology and medicine. In addition, [REDACTED] has established a center for human embryonic stem cell research and education, which is housed in our regenerative medicine institute. Program activities form a foundation for research and include a comprehensive course on Stem Cell Biology and Regenerative Medicine to educate CIRM Scholars regarding stem cells and applications to human disease, and opportunities to provide non-medical CIRM Scholars with an understanding of the considerations necessary to translate basic research to the clinic. Courses in Biomedical Ethics, Responsible Conduct of Research, basic and advanced courses in human embryonic stem cell (hESC) and pluripotent stem cell biology, a seminar series [REDACTED], an annual retreat and a robust program in stem cells and Society offer additional and unique educational opportunities. We seek funding for our Type I comprehensive training program with 16 concurrent positions devoted to 6 predoctoral, 5 postdoctoral, and 5 clinical fellow CIRM Scholars.
This application proposes to continue and expand our CIRM-funded integrated training and research program in the fundamental biology of embryonic, adult, and reprogrammed-stem cell research and its applications to human disease. We aim to produce leaders positioned to understand basic stem cell mechanisms, develop relevant human stem cell lines in order to investigate the pathogenesis and treatment of diseases, and provide the fundamental and practical basis for the development of new molecular and cellular therapies. These activities have significant implications for the State of California and its citizens. We are requesting CIRM funds in order to continue our highly successful Research Training Program, with 6 predoctoral, 5 post-doctoral and 5 clinical fellow trainees for a total of 16 concurrent CIRM Scholar positions. Trainees will have the opportunity to learn from pre-eminent stem cell biologists as well as physicians, scientists and physician-scientists at one of the State’s leading academic institutions. Furthermore, our program in Regenerative Medicine, with which trainees are closely associated, represents a unique University-wide collaboration that brings together over 150 faculty members in life, physical, and engineering sciences, together with leaders in business, law, and education. This CIRM Research Training Program proposal will provide real benefits to the State of California and its citizens in the following ways: First, all trainees will be exposed to vital medical issues amongst Californian patients and this will foster new ideas and lead to exploration of novel strategies with associated faculty in their pursuits of novel stem cell therapies. Second, our programmatic activities including courses, seminars, annual retreats, symposia and journal club components as part of this training program, will serve to connect with a much greater number of student, fellows, and basic and clinical faculty across the disciplines, from Biochemistry to Law and Business to Medicine from across the campus in all seven schools and across the State. Third, this training program has significant potential to provide the support and momentum to explore advances in stem cell biology and novel therapies which will further attract additional world class faculty over the next decade. Finally, by bringing together our stem cell faculty and trainees in one program, and connecting and coordinating (via our program in Regenerative Medicine), our efforts across the campus will maximize our capability to develop innovative new diagnostics, tools, and novel therapies in stem cell biology and regenerative medicine and also gain the attention and momentum of researchers across the campus and beyond. These innovations ultimately promise to improve the lives of Californians and bring additional research talent and business into the State.
The aim of the Stanford CIRM Training Program is to produce leaders positioned to understand basic stem cell mechanisms, develop relevant human stem cell lines in order to investigate the pathogenesis and treatment of diseases, and provide the fundamental and practical basis for the development of new molecular and cellular therapies. As such, the training program aims to integrate studies in basic and clinical sciences to foster a translational approach to biomedical research. The training program seeks to intersect basic and clinical science with a specific emphasis on Stem Cell Biology and Regenerative Medicine; referred to as “Translational Medicine.” In this regard, Stanford offers outstanding opportunities for training both MD and PhD predoctoral students, PhD postdoctoral fellows, and clinical fellows in stem cell biology, regenerative medicine, and human disease. Stanford brings a powerful combination of assets to this mission with the School of Medicine, the Hospitals and Clinics and the University all on one campus. In addition, Stanford faculty have extensive experience in basic research, clinical translation, and training in stem cells and cancer stem cells. To date, we have trained 17 Clinical Fellows, 17 Postdoctoral Scholars and 27 Pre-doctoral Students; many of which have gone on to faculty positions or have received other pretigious awards to continue their training in California.
The aim of the Stanford CIRM Training Program is to produce leaders positioned to understand basic stem cell mechanisms, develop relevant human stem cell lines in order to investigate the pathogenesis and treatment of diseases, and provide the fundamental and practical basis for the development of new molecular and cellular therapies. As such, the training program aims to integrate studies in basic and clinical sciences to foster a translational and entrepreneurial approach to biomedical research. The training program seeks to intersect basic and clinical science with a specific emphasis on using fundamental principles in biology and medicine to improve human health. Stanford University consists of a single integrated campus that hosts research and training programs in the humanities, law, business biological sciences, physical sciences, engineering, and computer sciences. The Stanford CIRM Training Program supports trainees in a rich cross-disciplinary atmosphere of discovery and translation. The Stanford CIRM Training Program offers outstanding opportunities for both MD and PhD predoctoral students, PhD postdoctoral fellows, and clinical fellows in stem cell biology, regenerative medicine, and human disease. The Stanford faculty mentors have extensive experience in basic research, clinical translation, and training in stem cells and cancer stem cells.
In combination, our CIRM Training Faculty have trained 18 Clinical Fellows, 18 Postdoctoral Scholars and 29 Predoctoral Students; many of which have gone on to faculty positions or have received other prestigious awards to continue their training and research in California.
The Stanford CIRM Training Grants I and II have supported scientific training in stem cell biology and regenerative medicine from 2006 through 2015. CIRM has discontinued the Training Grant program in California but during the 9-year term of operation, the CIRM training awards supported one of the most scientifically and clinically productive training programs at the Stanford School of Medicine. Over the entire 9 year training program, the CIRM Training Grant awards at Stanford have attracted a total of 70 trainees. Of these, 24 are now independent faculty-level scientists or practicing physicians who hold appointments at Stanford, Harvard, UCLA, USC, UC Irvine and many other leading biomedical research institutions in the US and abroad. Many trainees who entered the field with CIRM support will be continuing their graduate or postdoctoral training. During the last 3 years of support, the Stanford CIRM Training Grant has enabled 18 doctoral students, 8 clinical fellows, and 6 postdoctoral fellows to begin their specialized training. To date, these 32 trainees have authored or co-authored more than 46 scientific publications that highlight fundamental biological advances and the translation of stem cell technologies into new clinical and biomedical applications. Overall, the CIRM training programs at Stanford have been extraordinarily successful in bringing new professionals into the rapidly expanding new discipline of Stem Cell Biology and Regenerative Medicine.
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- Proc Natl Acad Sci U S A (2014) Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. (PubMed: 24550281)
- Nat Commun (2014) Discriminating cellular heterogeneity using microwell-based RNA cytometry. (PubMed: 24667995)
- Nat Med (2014) Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. (PubMed: 24859528)
- Sci Rep (2014) Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies. (PubMed: 25242416)
- Stem Cell Reports (2014) Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1. (PubMed: 25254342)
- Nat Med (2014) Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. (PubMed: 24531378)
- Nat Neurosci (2013) Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. (PubMed: 23313911)
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- Cell (2013) Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. (PubMed: 23582327)
- Proc Natl Acad Sci U S A (2013) Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-catenin-responsive neural stem cells. (PubMed: 23589866)
- J Exp Med (2013) Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. (PubMed: 23669396)
- Nature (2013) SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. (PubMed: 24132240)
- Cell (2013) Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. (PubMed: 24243019)
- Integr Biol (Camb) (2013) Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids. (PubMed: 24343706)
- Cell (2012) TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends. (PubMed: 22863003)
- Cell Stem Cell (2012) Developmental Stage and Time Dictate the Fate of Wnt/beta-Catenin-Responsive Stem Cells in the Mammary Gland. (PubMed: 22863533)
- Curr Opin Genet Dev (2012) The many roads to Rome: induction of neural precursor cells from fibroblasts. (PubMed: 22868177)
- Curr Neurol Neurosci Rep (2012) Modeling Parkinson's disease using induced pluripotent stem cells. (PubMed: 22538490)
- Mol Cell (2012) Molecular roadblocks for cellular reprogramming. (PubMed: 23020854)
- Cell Stem Cell (2012) A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. (PubMed: 23122292)
- Proc Natl Acad Sci U S A (2012) Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. (PubMed: 22308465)
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