Battling COVID-19 Using Off-The-Shelf HSC-Engineered iNKT Cells

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Grant Award Details

Grant Type:
Discovery Research Projects
Grant Number:
DISC2COVID19-12020
Investigator(s):
Name:
Dr. Lili Yang
Institution:
University of California, Los Angeles
Type:
PI

Disease Focus:
COVID-19, Infectious Disease
Human Stem Cell Use:
Adult or Tissue Stem Cell
Award Value:
$250,000
Status:
Closed

Grant Application Details

Application Title:

Battling COVID-19 Using Off-The-Shelf HSC-Engineered iNKT Cells

Public Abstract:
Research Objective

allogeneic HSC-engineered iNKT (HSC-iNKT) cells

Impact

treatment for COVID-19

Major Proposed Activities

  • Milestone 1. Production of AlloHSC-iNKT and UHSC-iNKT cells
  • Milestone 2. Characterization of the AlloHSC-iNKT and UHSC-iNKT cells
  • Milestone 3. Delivery of the new therapeutic candidate
Statement of Benefit to California:
The novel SARS-CoV-2 is the cause of the coronavirus disease 19 (COVID-19) pandemic, which is responsible for over 10.3 million cases and 500,000 deaths worldwide. There are over 2.6 million COVID-19 cases in the US, including over 217,000 cases in California. The proposed off-the-shelf allogeneic HSC-engineered iNKT (HSC-iNKT) cell therapy, if successful, may provide a treatment and save lives of COVID-19 patients at California.