Grant Award Details
- Goal of this project is to conduct a Phase 1/2 clinical trial to evaluate safety and efficacy of LVgp120 duo CAR-T cells in HIV infected patients in the absence of ART.
Grant Application Details
- Anti-HIV duoCAR-T cell therapy for HIV infection
Therapeutic Candidate or Device
HIV-specific CAR-T cells
Management of HIV infection
We will modify T cells such that they are able to directly control HIV in the absence of therapy. Should this work, these cells will result in long-term control of HIV in absence of any ongoing treatment, a version of a HIV "cure". We are developing methods to make such an approach safe, scalable and affordable.
Unmet Medical Need
Many people are not able to access and adhere to long-term antiretroviral therapy. This approach will address the needs to those who are not able to respond to current approaches, which we estimate to be up to 50% of those affected by HIV globally.
Phase I study completed
Major Proposed Activities
- Manufacture of the LVgp120duoCAR vector
- Completion of a phase I/IIa dose-escalation clinical trial
- Optimize the development process to make the product affordable and scalable
The HIV pandemic in the United States largely started in the major urban centers of California and New York. Many of those infected with HIV in California are having challenges tolerating antiretroviral therapy; this is particularly true for the first generation of survivors as they require complex regimens. Many other people have socioeconomic and other barriers that prevent them from responding to current approaches. A "single-shot" cure for HIV would address many of these limitations.