Human Stem Cell Use: Embryonic Stem Cell

The University of California: Irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course

A major goal of the Shared Research Laboratory (SRL) is to foster the development of new treatments for human diseases and disorders by serving as a leading regional center for human embryonic stem cell (hESC) research, clinical applications, and training. A critical component of this vision is a full service SRL. The SRL will provide […]

Collaborative Laboratory for Human Embryonic Stem Cell Research at Sanford-Burnham Medical Research Institute

We are proposing to expand our “safe haven” human embryonic stem cell laboratory to accommodate the enormous interest in scientific research in this field, and to provide an environment that is conducive to the goals of the CIRM’s Strategic Plan. Our collaborative Shared Laboratory will support the research of all of our institution’s many stem […]

North Bay CIRM Shared Research Laboratory for Stem Cells and Aging

Age-related diseases of the nervous system are major challenges for biomedicine in the 21st century. These disorders, which include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and stroke, cause loss of neural tissue and functional impairment. Currently, there is no cure for these devastating neurological disorders. A promising approach to the treatment of […]

Shared viral vector facility for genetic manipulation of huamn ES cell

Human ES (hES) cells offer the opportunity to be converted into replacement tissues for diseased organs and provide cures for diseases like Parkinson’s, diabetes, and a host of neurological disorders. Unfortunately due to political considerations, scientific space containing equipment and other resources provided by the federal government are off limits for work on unapproved hES […]

Laying the groundwork for building a tooth: analysis of dental epithelial stem cells

To fix a broken car, the mechanic either repairs or replaces the defective part. Similarly, one of the most promising approaches physicians foresee for treating human disease and ameliorating the aging process is regenerative medicine. A major aim of this field is to restore function by repairing or replacing damaged organs. Scientists envision a day […]

Building Cardiac Tissue from Stem Cells and Natural Matrices

Congestive heart failure afflicts 4.8 million people, with 400,000 new cases each year. Myocardial infarction (MI), also known as a “heart attack”, leads to a loss of cardiac tissue and impairment of left ventricular function. Because the heart does not contain a significant number of multiplying stem, precursor, or reserve cells, it is unable to […]

Mechanisms in Choroid Plexus Epithelial Development

Buried deep inside the brain are cells known as choroid plexus epithelial (CPe) cells. Although not as famous as other cells in the nervous system, CPe cells perform a large number of important jobs that keep the brain and spinal cord healthy. They produce the fluid (known as cerebrospinal fluid, or CSF) that bathes the […]

The roles of non-coding RNAs in the self-renewal and differentiation of pluripotent stem cells

There are thousands of cell types in the animal body, many of which can be derived from embryonic stem cells (ES cells), a pluripotent cell type that thrive in cell culture condition. ES cells differentiate into various cell type in a tissue culture dish in response to different growth factor/cytokine treatment, which can be transplanted […]

Mechanisms of small RNA regulation in early embryonic development

The promise of embryonic stem cells in regenerative medicine is based on their potential to make every cell in the body, a property coined pluripotency. With rapid recent advances in technology, it is becoming relative straightforward to make embryonic stem cell-like lines from adult tissues. In the near future, the generation of these lines will […]

Mechanisms Underlying the Diverse Functions of STAT3 in Embryonic Stem Cell Fate Regulation

Embryonic stem cells (ESCs) are derived from very early stage embryos. ESCs can be maintained in culture indefinitely while retain the ability to make any type of cell in the body. These properties make ESCs a very powerful tool to address basic biology questions. ESCs also offer an important renewable resource for future cell replacement […]