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Targeting pancreatic cancer with Allogeneic Off-the-Shelf PSCA-CAR NK cells

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate PSCA-CAR_sIL15 NK cells derived from CD34(+) umbilical cord blood hematopoietic stem cells Area of Impact patients with metastatic pancreatic cancer or other cancers that also highly express PSCA…

Continue ReadingTargeting pancreatic cancer with Allogeneic Off-the-Shelf PSCA-CAR NK cells

Neurogenic hydrogel stimulation of stem cells to regenerate radiation-damaged salivary glands

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate Ceviginate is a neuromimetic encapsulated in a hydrogel Area of Impact Dry mouth as a result of injury to the salivary glands by radiation therapy for head and…

Continue ReadingNeurogenic hydrogel stimulation of stem cells to regenerate radiation-damaged salivary glands

Adenine Base Editing for Autologous Hematopoietic Stem Cell Gene Therapy of CD3δ SCID

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate The translational candidate is Autologous Hematopoietic Stem and Progenitor Cells from CD3δ SCID Patients Corrected by Adenine Base Editing Area of Impact The candidate will provide treatment for…

Continue ReadingAdenine Base Editing for Autologous Hematopoietic Stem Cell Gene Therapy of CD3δ SCID

Pro-regenerative infusible ECM biomaterial for treating acute myocardial infarction

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate Injectable biomaterial derived from the natural scaffolding of pig hearts Area of Impact Improving the quality of life of patients with heart attacks Mechanism of Action The proposed…

Continue ReadingPro-regenerative infusible ECM biomaterial for treating acute myocardial infarction

Ex Vivo Modified Hematopoietic Stem Cells to Treat Danon Disease

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate The candidate is CD34+ HSPCs transduced ex vivo with a LAMP2 lentiviral vector. Area of Impact Danon Disease, Lysosomal Storage Diseases, Drug Development for Rare Disease Mechanism of…

Continue ReadingEx Vivo Modified Hematopoietic Stem Cells to Treat Danon Disease

Hematopoietic Stem Cell Gene Editing for X-linked Agammaglobulinemia (XLA)

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate Autologous CD34+ hematopoietic stem and progenitor cells (HSPC) with BTK gene insertion for treatment of X-linked agammaglobulinemia (XLA). Area of Impact The candidate will provide improved outcomes for…

Continue ReadingHematopoietic Stem Cell Gene Editing for X-linked Agammaglobulinemia (XLA)

Targeting multiple myeloma with BCMA-CAR NK cells expressing a GPRC5D-NKG2D bispecific antibody

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate s15.BsAb.BCMA-CAR NK cells derived from CD34(+) umbilical cord blood hematopoietic stem cells Area of Impact patients with multiple myeloma Mechanism of Action s15.BsAb.BCMA-CAR NK cells are umbilical cord…

Continue ReadingTargeting multiple myeloma with BCMA-CAR NK cells expressing a GPRC5D-NKG2D bispecific antibody

Hematopoietic Stem Cell Gene Therapy for Wiskott Aldrich Syndrome

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate Human hematopoietic stem cells that have been modified to express a functional WAS gene to treat patients with Wiskott Aldrich Syndrome (WAS) Area of Impact These studies will…

Continue ReadingHematopoietic Stem Cell Gene Therapy for Wiskott Aldrich Syndrome

Hematopoietic Stem/Progenitor Cell-Based Chimeric Antigen Receptor Gene Therapy for HIV Infection

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate A blood forming stem cell based therapy to treat HIV infection and enhance HIV immunity. Area of Impact We are seeking to develop a therapy to treat HIV…

Continue ReadingHematopoietic Stem/Progenitor Cell-Based Chimeric Antigen Receptor Gene Therapy for HIV Infection

Extracellular Vesicle-Based Therapy for Corneal Scars

  • Post author:
  • Post published:June 5, 2025
  • Post category:

Translational Candidate Extracellular vesicles derived from stem cells for the treatment of corneal scars. Area of Impact The candidate aims to restoring vision by reducing the need for corneal transplant…

Continue ReadingExtracellular Vesicle-Based Therapy for Corneal Scars
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