Disease Focus: Tendon/Ligament/Connective Tissue Injury or Disorder

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The role of WNT and BMP signaling pathways in iPSC to iTenocyte step-wise differentiation for tendon repair

Research Objective Development-inspired differentiation will enable efficient and specific generation of tenocytes that can repair tendon injury, restore dysfunctional tissue, and prevent long term effects. Impact This study will eliminate heterogenous differentiation of pluripotent stem cells and will results in high yield and unified tenogenic phenotype. Major Proposed Activities Establish the mechanism by which Wnt […]

Pluripotent Stem Cells for Tendon Tissue Engineering

Research Objective We propose to develop a bio-tendon engineered from differentiated pluripotent stem cells for the repair of tendon injuries and degeneration. Impact Rotator cuff tears are the most common causes of shoulder pain that require surgery. However, failure rates range from 20% to 90%. A successful tendon repair will have a major impact on […]