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Preclinical Development and First-In-Human Testing of GRNCM1 in Advanced Heart Failure

  • Post author:
  • Post published:September 12, 2025
  • Post category:

This application seeks to bring to the clinic a new treatment for myocardial disease based on human embryonic stem cell (hESC) derived cardiomyocytes. hESC-cardiomyocytes have the unique potential to address…

Continue ReadingPreclinical Development and First-In-Human Testing of GRNCM1 in Advanced Heart Failure

Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure

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  • Post published:September 12, 2025
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Patients with end-stage heart failure (ESHF) have a 2-year survival rate of 50% with conventional medical therapy. This dismal survival rate is actually significantly worse than patients with AIDS, liver…

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Mechanisms of Direct Cardiac Reprogramming

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  • Post published:September 12, 2025
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Heart disease is a leading cause of adult and childhood mortality. The underlying pathology is typically loss of heart muscle cells that leads to heart failure, or improper development of…

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Elucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells

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  • Post published:September 12, 2025
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Familial hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in young people, including trained athletes, and is the most common inherited heart defect. Until now, studies in…

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Characterization and Engineering of the Cardiac Stem Cell Niche

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  • Post published:September 12, 2025
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Despite therapeutic advances, cardiovascular disease remains a leading cause of mortality and morbidity in both California and Europe. New insights into disease pathology, models to expedite in vitro testing and…

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Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC

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  • Post published:September 12, 2025
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Heart disease is the number one cause of death and disability in California and in the United States. Especially devastating is Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), an inherited form of…

Continue ReadingMolecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC

Antibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs

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  • Post published:September 12, 2025
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Purity is as important for cell-based therapies as it is for treatments based on small-molecule drugs or biologics. Pluripotent stem cells possess two properties: they are capable of self regeneration…

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Engineering microscale tissue constructs from human pluripotent stem cells

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  • Post published:September 12, 2025
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Tissues derived from stem cells can serve multiple purposes to enhance biomedical therapies. Human tissues engineered from stem cells hold tremendous potential to serve as better substrates for the discovery…

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Engineering Cardiac Tissue for Regeneration and Drug Development

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  • Post published:September 12, 2025
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The ‘valley of death’ in scientific parlance refers to the time period where biomedical discovery in the laboratory fails to result in a cure for a disease. While the last…

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Transcriptional Regulation of Cardiac Pacemaker Cell Progenitors

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  • Post published:September 12, 2025
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Congenital and acquired defects of cardiac pacemakers are leading causes of morbidity and mortality in our society. Dysfunctions of the SA node and the lower conduction cells lead to a…

Continue ReadingTranscriptional Regulation of Cardiac Pacemaker Cell Progenitors
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