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Induction of Pluripotent Stem Cell-Derived Pacemaking Cells

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  • Post published:September 28, 2025
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Currently, over 350,000 patients per year with abnormal heart rhythm receive electronic pacemakers to restore their normal heart beat. Electronic pacemakers do not respond to the need for changing heart…

Continue ReadingInduction of Pluripotent Stem Cell-Derived Pacemaking Cells

Studying Arrhythmogenic Right Ventricular Dysplasia with patient-specific iPS cells

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  • Post published:September 28, 2025
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Most heart conditions leading to sudden death or impaired pumping heart functions in the young people (

Continue ReadingStudying Arrhythmogenic Right Ventricular Dysplasia with patient-specific iPS cells

Mechanism of heart regeneration by cardiosphere-derived cells

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  • Post published:September 28, 2025
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In the process of a heart attack, clots form suddenly on top of cholesterol-laden plaques, blocking blood flow to heart muscle. As a result, living heart tissue dies and is…

Continue ReadingMechanism of heart regeneration by cardiosphere-derived cells

A new paradigm of lineage-specific reprogramming

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  • Post published:September 28, 2025
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Recently, we devised and reported a new regenerative medicine paradigm that entails temporal/transient overexpression of induced pluripotent stem cell based reprogramming factors in skin cells, leading to the rapid generation…

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Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure

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  • Post published:September 28, 2025
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Patients with end-stage heart failure have a 2-year survival rate of only 50% with conventional medical therapy. This dismal survival rate is actually significantly worse than patients with AIDS, liver…

Continue ReadingHuman Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure

Allogeneic Cardiac-Derived Stem Cells for Patients Following a Myocardial Infarction

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  • Post published:September 28, 2025
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The proposed research will demonstrate both safety and efficacy of a heart-derived stem cell product in patients who have experienced a heart attack either recently or in the past by…

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Direct Cardiac Reprogramming for Heart Regeneration

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  • Post published:September 28, 2025
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Heart disease is a leading cause of mortality. The underlying pathology is typically loss of heart muscle cells that leads to heart failure. Because heart muscle has little or no…

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Human ES cell based therapy of heart failure without allogenic immune rejection

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  • Post published:September 28, 2025
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Heart failure is a major and ever-growing health problem affecting an estimated 5.8 million Americans with about half a million new cases every year. There are limited therapeutic options for…

Continue ReadingHuman ES cell based therapy of heart failure without allogenic immune rejection

Heart Repair with Human Tissue Engineered Myocardium

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  • Post published:September 28, 2025
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Heart disease is the number one cause of morbidity and mortality in the US. With an estimated 1.5 million new or recurrent myocardial infarctions, the total economic burden on our…

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Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease

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  • Post published:September 28, 2025
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Autophagy is the cells mechanism for breaking down and recycling proteins. Danon disease is an inherited disorder of autophagy. Patients with this disease have major abnormalities in heart and skeletal…

Continue ReadingIdentification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease
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