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A Center for Stem Cell Disease Modeling and Therapeutics

  • Post author:
  • Post published:June 9, 2025
  • Post category:

The goal of this project is to support the discovery and evaluation of novel therapeutics using stem cell-based models and drug and CRISPR screening. The facility will provide California researchers…

Continue ReadingA Center for Stem Cell Disease Modeling and Therapeutics

Stem Cell-based Disease Modeling Shared Resource Laboratory

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Our Shared Resource Laboratory will expand access to stem cell-derived models to support research and educational programs with two main goals: democratize access to state-of-the-art models and technology among a…

Continue ReadingStem Cell-based Disease Modeling Shared Resource Laboratory

Mapping and modeling endothelial cell fate decisions for pulmonary arterial hypertension

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective We will build a foundational model and experimental platform to catalog all genes that promote and protect against PAH, with the potential to extend to many other developmental…

Continue ReadingMapping and modeling endothelial cell fate decisions for pulmonary arterial hypertension

Drug Discovery for Dilated Cardiomyopathy using Patient-Derived Human iPSCs

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective Greenstone Biosciences will use patient-derived stem cells to discover safe and effective drugs for cardiovascular disease. Impact The use of patient-derived stem cells to discover novel drug targets…

Continue ReadingDrug Discovery for Dilated Cardiomyopathy using Patient-Derived Human iPSCs

Modulating cardiac myosin heavy chain isoform expression for treating cardiomyopathies

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective To discover CRISPR-based genetic strategies that will directly and therapeutically modify cardiac myosin heavy chain isoform expression to treat HF and cardiomyopathies. Impact Heart Failure and Cardiomyopathies Major…

Continue ReadingModulating cardiac myosin heavy chain isoform expression for treating cardiomyopathies

RNA-based therapeutics to augment regulatory T cells: a novel approach to treat myocarditis

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective Use human cell therapy insights, specifically CDC-secreted EV analysis, to develop a noncoding RNA chemical entity for myocarditis treatment. Impact Key knowledge gap is how to recruit adaptive…

Continue ReadingRNA-based therapeutics to augment regulatory T cells: a novel approach to treat myocarditis

Novel Lipid Nanoparticles for Enhancing eNOS Synthesis for Cardioprotection Post Myocardial Infarction

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective Our therapeutic candidate is a lipid nanoparticle that delivers a therapeutic dose of mRNA to the human heart, which transiently transfects of cells within the heart to improve…

Continue ReadingNovel Lipid Nanoparticles for Enhancing eNOS Synthesis for Cardioprotection Post Myocardial Infarction

Modified RNA-Based Gene Therapy for Cardiac Regeneration Through Cardiomyocyte Proliferation

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective Efficacious and safe intramyocardial delivery of modified mRNA encoding cell cycle regulators as a gene therapy for cardiac regeneration through resident cardiomyocyte proliferation. Impact This project would provide…

Continue ReadingModified RNA-Based Gene Therapy for Cardiac Regeneration Through Cardiomyocyte Proliferation

Cardiac Reprogramming Gene Therapy for Post-Myocardial Infarction Heart Failure

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective The candidate is a gene therapy that delivers cardiac reprogramming factors to convert resident cardiac fibroblasts into functioning cardiac muscle. Thus, it is a regenerative cardiac gene therapy.…

Continue ReadingCardiac Reprogramming Gene Therapy for Post-Myocardial Infarction Heart Failure

A novel hybrid CRISPR tool for gene network perturbation and hiPSC engineering

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Research Objective A CRISPR-based tool for simultaneous up- and downregulation of many (~5-20) genes, and a computational tool using scRNA-seq data to predict which genes to perturb for efficacious cell-type…

Continue ReadingA novel hybrid CRISPR tool for gene network perturbation and hiPSC engineering
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