Hearing loss is the leading birth defect in the United States with ~3 children in 1,000 born with partial to profound compromise of auditory function. Debilitating hearing loss is estimated…
Hair cells (HCs) convert sound and balance signals into electrical impulses in the inner ear, including the cochlea and the vestibular endorgans, with remarkable precision and sensitivity. Our long-term goal…
Research Objective We aim to identify drug regimens that stimulate endogenous progenitors in the inner to regenerate to restore hearing or balance functions. Impact Treatment for irreversible hearing loss and…
Research Objective Development of a screen using inner ear sensory hair cell-like cells made by direct lineage reprogramming, for discovering drugs to ameliorate hearing loss during cancer chemotherapy. Impact Hearing…
Therapeutic Candidate or Device B cells will be isolated from patients suffering MPSI. These will be transformed with a normal copy of the gene and re-introduced into the patient Indication…
Hearing loss (HL) is a permanent sensory disorder affecting over 278 million people worldwide. In the US and California, 20% of individuals suffer from this sensory deficit. Those affected range…
Robert Klein, J.D. and Claire Pomeroy, M.D., M.B.A., gave the welcoming remarks for the "Spotlight on Deafness," an educational event presented at the CIRM Governing Board meeting on March 12,…
Karen Doyle, M.D., Ph.D., spoke at the "Spotlight on Deafness," an educational event presented at the CIRM Governing Board meeting on March 12, 2008. Dolye briefly summarized the current clinical…
Ebenezer N. Yamoah, Ph.D. spoke at the "Spotlight on Deafness," an educational event presented at the CIRM Governing Board meeting on March 12, 2008. Yamoah overviewed the biological mechanisms of…
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