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Dual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication

  • Post author:
  • Post published:May 20, 2025
  • Post category:

Leukemia is the most frequent form of cancer in children and teenagers, but is also common in adults. Chemotherapy has vastly improved the outcome of leukemia over the past four…

Continue ReadingDual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication

Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy

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  • Post published:May 20, 2025
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Cancer is the leading cause of death for individuals under 85. Relapse and metastatic disease are the leading causes of cancer related mortality. Anti-apoptotic BCL2 family member overexpression has been…

Continue ReadingPreclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy

Niche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors

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  • Post published:May 20, 2025
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Bone marrow and peripheral blood transplantation utilizing blood stem cells can provide curative treatment for patients with cancers and non-cancerous diseases of the blood and immune systems. Such treatments can…

Continue ReadingNiche-Focused Research: Discovery & Development of Hematopoietic Regenerative Factors

The role of neural stem cells in cerebellar development, regeneration and tumorigenesis

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  • Post published:May 20, 2025
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Stem cells have the remarkable ability to renew themselves and to generate multiple different cell types. This allows them to generate normal tissues during development and to repair tissues following…

Continue ReadingThe role of neural stem cells in cerebellar development, regeneration and tumorigenesis

Epigenetics in cancer stem cell initiation and clinical outcome prediction

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  • Post published:May 20, 2025
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Cancer is responsible for approximately 25% of all deaths in the US and other developed countries. For women, breast and lung cancers and for men, cancers of prostate and lung…

Continue ReadingEpigenetics in cancer stem cell initiation and clinical outcome prediction

Combinatorial Chemistry Approaches to Develop LIgands against Leukemia Stem Cells

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  • Post published:May 20, 2025
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Various cells and organs in the human body originate from a small group of primitive cells called stem cells. Human cancer cells were also recently found to arise from a…

Continue ReadingCombinatorial Chemistry Approaches to Develop LIgands against Leukemia Stem Cells

Mechanisms of Hematopoietic stem cell Specification and Self-Renewal

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  • Post published:May 20, 2025
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During an individual’s lifetime, blood-forming cells in the bone marrow called hematopoietic stem cells (HSCs) supply all the red and white blood cells needed to sustain life. These blood stem…

Continue ReadingMechanisms of Hematopoietic stem cell Specification and Self-Renewal

Mechanisms Underlying the Responses of Normal and Cancer Stem Cells to Environmental and Therapeutic Insults

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  • Post published:May 20, 2025
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Adult stem cells play an essential role in the maintenance of tissue homeostasis. Environmental and therapeutic insults leading to DNA damage dramatically impact stem cell functions and can lead to…

Continue ReadingMechanisms Underlying the Responses of Normal and Cancer Stem Cells to Environmental and Therapeutic Insults

Stem Cells for Immune System Regeneration to Fight Cancer

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  • Post published:May 20, 2025
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This proposal will define the biology of stem cell engineering to produce a cancer-fighting immune system. The immune system protects our body against most outside threats. However, it frequently fails…

Continue ReadingStem Cells for Immune System Regeneration to Fight Cancer

Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells

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  • Post published:May 20, 2025
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Cancer is the leading cause of death for people younger than 85. High cancer mortality rates related to resistance to therapy and malignant progression underscore the need for more sensitive…

Continue ReadingDerivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells
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