Disease Focus: Brain Cancer
Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)
Brain tumors (BTs) are incurable, whether they start in the brain or spread there from other sites. Despite advances in surgical, radiation, pharmacologic, and gene therapies, survival with a BT remains dismal. Current therapies are limited by their inability to reach widely disseminated tumor cells that become dispersed within normal brain structures. Interestingly, the therapeutic […]
Stem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials
Despite aggressive multimodal therapy and advances in imaging, surgical and radiation techniques, malignant brain tumors (high-grade gliomas) remain incurable, with survival often measured in months. Treatment failure is largely attributable to the diffuse and invasive nature of these brain tumor cells, ineffective delivery of chemotherapeutic agents to tumor sites, and toxic side-effects to the body, […]
Brain Tumors: Advancing Stem Cell Therapies – 2011 CIRM Grantee Meeting
Karen Aboody speaks at the 2011 CIRM Grantee Meeting about the developing a stem cell-based clinical trial for malignant brain tumors. Dr. Aboody and her team at the City of Hope Hospital medical center in Duarte, have been funded by CIRM to create a human neural cell line with the ability to target brain tumor […]