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Development of small molecule screens for autism using patient-derived iPS cells

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  • Post published:December 20, 2025
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Autism Spectrum Disorders (ASDs) are a heritable group of neuro-developmental disorders characterized by language impairments, difficulties in social integrations, and the presence of stereotyped and repetitive behaviors. There are no…

Continue ReadingDevelopment of small molecule screens for autism using patient-derived iPS cells

Site-specific integration of Lmx1a, FoxA2, & Otx2 to optimize dopaminergic differentiation

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  • Post published:December 20, 2025
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The objective of this study is to develop a new, optimized technology to obtain a homogenous population of midbrain dopaminergic (mDA) neurons in a culture dish through neuronal differentiation. Dopaminergic…

Continue ReadingSite-specific integration of Lmx1a, FoxA2, & Otx2 to optimize dopaminergic differentiation

Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders

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  • Post published:December 20, 2025
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Our research group at [REDACTED] has had a long-standing interest in understanding the cause of several disorders that result in severe, and often times fatal forms of diarrhea in children.…

Continue ReadingPluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders

Stem Cell Therapy for Duchenne Muscular Dystrophy

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  • Post published:December 20, 2025
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Duchenne muscular dystrophy (DMD) is the most common and serious form of muscular dystrophy. One out of every 3500 boys is born with the disorder, and it is invariably fatal.…

Continue ReadingStem Cell Therapy for Duchenne Muscular Dystrophy

Developing a therapeutic candidate for Canavan disease using induced pluripotent stem cell

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  • Post published:December 20, 2025
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Canavan disease is a devastating disease of infants which affects their neural development and leads to mental retardation and early death. It occurs in 1 in 6,400 persons in the…

Continue ReadingDeveloping a therapeutic candidate for Canavan disease using induced pluripotent stem cell

Crosstalk: Inflammation in Parkinson’s disease (PD) in a humanized in vitro model

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  • Post published:December 20, 2025
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Parkinson’s Disease (PD) is the most common neurodegenerative movement disorder. It is characterized by motor impairment such as slowness of movements, shaking and gait disturbances. Age is the most consistent…

Continue ReadingCrosstalk: Inflammation in Parkinson’s disease (PD) in a humanized in vitro model

Developing a drug-screening system for Autism Spectrum Disorders using human neurons

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  • Post published:December 20, 2025
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Autism and autism spectrum disorders (ASD) are complex neurodevelopmental diseases that affect 1 in 150 children in the United States. Such diseases are mainly characterized by deficits in verbal communication,…

Continue ReadingDeveloping a drug-screening system for Autism Spectrum Disorders using human neurons

Epithelial progenitors and the stromal niche as therapeutic targets in lung disease

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  • Post published:December 20, 2025
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Chronic lung disease is an enormous societal and medical problem in California and the nation as a whole, representing the third most likely cause of death. Treatment costs were $389.2…

Continue ReadingEpithelial progenitors and the stromal niche as therapeutic targets in lung disease

Development of Cellular Therapies for Retinal Disease

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  • Post published:December 20, 2025
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The long term goal of our research program is regeneration of the diseased eye. Age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa are leading causes of blindness for which there…

Continue ReadingDevelopment of Cellular Therapies for Retinal Disease

In vitro reprogramming of mouse and human somatic cells to an embryonic state

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  • Post published:December 20, 2025
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Embryonic stem (ES) cells are remarkable cells in that they can replicate themselves indefinitely and have the potential to turn into all possible cell type of the body under appropriate…

Continue ReadingIn vitro reprogramming of mouse and human somatic cells to an embryonic state
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