This paper gives detailed instructions to those wanting to use the dual integrase cassette exchange (DICE) method. The DICE method is useful for making precise insertions into a mammalian genome at a pre-determined location. Because the method is efficient, it is suitable for making a series of different insertions at the same location. To date, the DICE method has been most utilized in the context of human induced pluripotent stem cells. The method provides a much-needed genetic engineering tool for these iPSC and is being used by academic labs and companies to engineer iPSC to increase basic science understanding and to develop therapeutics. Therefore, this article will allow other users to benefit from the expertise the Calos lab developed with the DICE method.