Understanding human embryogenesis by building programmable stem cell-based models.
Publication Year:
2025
PubMed ID:
40903365
Funding Grants:
Public Summary:
Stem cell-based embryo models
provide an alternative system to
study an elusive period of develop-
ment. Programmed mouse embryo
models have recently been gener-
ated by activating two endogenous
regulatory elements via epigenome
editing. In this forum article, we
discuss this achievement along
with the potential of translating it
to engineering models of human
embryogenesis.
Scientific Abstract:
Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.
