The authors studied migration of neural stem cell (NSC) migration with time-lapse and quantitative modelling methods. Using time-lapse imaging, the author analyzed the NSC mode of migration. Electric fields suppressed the formation of protrusions oriented toward the anode, suggesting that restriction of protrusions. The authors generated a model of NSC migration with only two key parameters, the probability that a cell will change direction and the probabilities for each of the directions the cell can take. This model can accurately reproduce experimental migration patterns.