Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives.

Journal: 
Adv Mater
Publication Year: 
2011
Authors: 
A Chen
D K Lieu
L Freschauf
V Lew
H Sharma
J Wang
D Nguyen
I Karakikes
R J Hajjar
A Gopinathan
E Botvinick
C C Fowlkes
R A Li
M Khine
PubMed link: 
22065428
Public Summary: 
A substrate for cell culture to create tunable multiscaled alignment "wrinkles" for the functional alignment of human embryonic stem cell derived cardiomyocytes.
Scientific Abstract: 
A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.