ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.

Robust control of human induced pluripotent stem cell (hIPSC) differentiation is essential to realize its patienttailored
therapeutic potential. Here, we demonstrate a novel application of Y-27632, a small molecule Rhoassociated
protein kinase (ROCK) inhibitor, to significantly influence the differentiation of hIPSCs in a lineagespecific
manner