Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.

Journal: 
Adv Healthc Mater
Publication Year: 
2016
Authors: 
Lei Cai
Ruby E Dewi
Andrew B Goldstone
Jeffrey E Cohen
Amanda N Steele
Y Joseph Woo
Sarah C Heilshorn
PubMed link: 
27709809
Funding Grants: 
Public Summary: 
A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.
Scientific Abstract: 
A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.
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