Zebrafish, on the other hand, have a remarkable ability to regenerate various body structures that mammals cannot, such as their jawbone. To explore whether zebrafish can also regenerate damaged joints, researchers developed a surgical model that destabilized the zebrafish jaw joint. By cutting a specific ligament, the researchers observed an initial decrease in jaw joint cartilage at 14 days, followed by full cartilage regeneration at 28 days.They then identified a group of chondrocytes marked by the expression of the gene sox10 as essential for joint cartilage regeneration. Single-cell analysis of the jaw joint revealed different cell subtypes, including a population expressing coch and grem1a genes that play a vital role in jaw joint chondrocytes during regeneration. In summary, zebrafish have demonstrated the ability to regenerate adult joint cartilage, and this research has identified potential cell types that may contribute to this regenerative process.