Alzheimer’s disease is the leading cause of dementia worldwide but curative therapies are lacking. Developing novel therapeutics for Alzheimer’s disease requires suitable experimental models that recapitulate complex human brain architecture and disease progression. Stem cell-derived three-dimensional tissues known as brain organoids contain several brain cell types and can be used to study Alzheimer’s disease in a laboratory setting. In this review, we highlight the versatility and numerous applications of brain organoids to study Alzheimer’s disease.