A Novel Approach for Subretinal Implantation of Ultrathin Substrates Containing Stem Cell-Derived Retinal Pigment Epithelium Monolayer.

Stem-cell based treatment strategies has the potency to cure diseases affecting the retinal pigment epithelium (RPE) which support photoreceptor survival and functionality. This study is intended to evaluate the feasibility of a new technique for the implantation of human embryonic stem cell-derived RPE cells (hESC-RPE) cultured as a monolayer on ultrathin parylene into the subretinal space of Royal College of Surgeon (RCS) rats which is considered as an RPE dysfunction disease model.