Klf4 Organizes Long-Range Chromosomal Interactions with the Oct4 Locus in Reprogramming and Pluripotency.

Klf4 is one of the factors that can convert somatic cells to iPS cells.This work describes that the 3D nuclear architecture changes during somatic cell reprogramming and how Klf4 changes the nuclear 3D structure of somatic cells to pluripotent stem cells.