Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells.

Here we report the derivation of a stem cell line from male germ cells, spermatogonia. The stem cell line can differentiate to diverse cell types in a dish (in vitro) but showed limited ability to form teratoma tumors in vivo in a mouse model. This suggested some properties in common with embryonic stem cells but also differences that may be important in considering stem cell therapies in the future.