iPS cells: insights into basic biology.

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Publication Year:

2009

Authors:

Miguel Ramalho-Santos

PubMed ID:

19703387

Funding Grants:

Transcriptional Regulation of Human Embryonic Stem Cells
Somatic cell age and memory in the generation of iPS cells

Public Summary:

This a review article where I propose that the process of iPS cell generation may provide important novel insights into basic biological processes, such regulation of gene activity during embryonic development or cellular transformation in cancer.

Scientific Abstract:

The discovery that adult somatic cells can be induced to become pluripotent by overexpression of a few key transcription factors provides an exciting new window into the basic biology of pluripotency and differentiation.