Inhibition of Pyruvate Oxidation Diminishes Melanoma Progression.

TO THE EDITOR Emerging evidence suggests that stem cell fate can be influenced by changes to pyruvate oxidation in the hair folli- cle, intestine, and brain (Flores et al, 2017; Petrelli et al, 2023; Schell et al, 2017). Cancers are thought to be driven by metabolic changes including increased glycolysis, namely the War- burg effect (Warburg, 1956b). It was previously established that inhibition of pyruvate oxidation can promote glycolysis and in some cases, promote tumorigenesis (Schell et al, 2014). In this study, we explored a role for pyru- vate oxidation in melanocyte stem cell homeostasis and melanoma formation.