Created of Warm Blood and Nerves: Restoring an Enteric Nervous System in Organoids.

Journal: 
Cell Stem Cell
Publication Year: 
2017
Authors: 
Christopher R Schlieve
Tracy C Grikscheit
PubMed link: 
28061353
Funding Grants: 
The generation and expansion of tissue-engineered small intestine from human stem/ progenitor cells: a preclinical study of functional translation
ASCENT- Advanced Stem Cell Enteric Neuropathy Therapy
Public Summary: 
The enteric nervous system (ENS) regulates numerous gastrointestinal functions, including epithelial barrier permeability and motility. In a recent Nature Medicine study, Workman et al. (2016) propose a method for introducing human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types and contractile function.
Scientific Abstract: 
The enteric nervous system (ENS) regulates numerous gastrointestinal functions, including epithelial barrier permeability and motility. In a recent Nature Medicine study, Workman et al. (2016) propose a method for introducing human pluripotent stem cell-derived enteric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types and contractile function.
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