Biological process activity transformation of single cell gene expression for cross-species alignment.

Journal: 
Nat Commun
Publication Year: 
2019
Authors: 
Hongxu Ding
Andrew Blair
Ying Yang
Joshua M Stuart
PubMed link: 
31653878
Public Summary: 
The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.
Scientific Abstract: 
The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.